Dresden lives in a spot on my heart right next to the Southern Vampire Mysteries. It is in this way that my reviews for both series are terribly skewed. That said, 'Blood Rites', by Jim Butcher, the sixth in a long chain of tales, is my favorite.
For fear of giving away too much - because that's so easy to do with these - this one has Dresden finding a puppy, getting himself hired to solve a mystery surrounding a porn set, all while working to try and defeat a new Black Court vampire nest. In true Dresden style, he stumbles his way through it all, cracking jokes, making deals (that may, or may not end up working in his favor), and taking names.
Seriously though, if you've never picked up a book in the series I urge you, (once again), to get out there and get cracking! This series is too good to miss. And if you're a Dresden fan already... well, you probably read this one years ago, but if you haven't gotten to it yet, this one is absolutely worth the read.